Safety of hair PRP with actinic keratosis spot on the scalp, advice?

This needs an in-person evaluation. I suggest seeing a hair loss expert now to go over your test results, condition and provide you information about your best treatment options. There are great non-invasive options like prp/progesterone which can help with hair regrowth and/or hair transplantation. See an expert. Best, Dr. Emer

Interesting and excellent question!  I believe the answer to this question may lie in the PRP technique. If PRP is utilized on top of the skin with micro-needling or intradermal injection, the possibility of actinic keratosis being stimulated exists. If one uses subdermal Depot injections, it is less likely that actinic keratosis would be affected. There are many different types of growth factors and cytokines in PRP and they can stimulate skin cells and blood vessels. Studies have not been done to evaluate whether this induces the growth of existing skin cancers. Since PRP does not enter the nucleus of existing normal cells, I don't believe it is mutagenic or can cause de novo (new)  skin cancer.

Nobody really knows this answer because studies have not been done. Many of the growth factors in PRP could theoretically favour progression of actinic keratoses en route to cancer. These include Vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), and fibroblast growth factor (FGF) which theoretically could trigger a variety of cell signaling mechanisms by stimulating cell surface receptors.  This topic needs study.