It's crucial to address any side effects or symptoms you experience while taking isotretinoin (Roaccutane) with your healthcare provider promptly. Fever is not a commonly reported side effect of isotretinoin, and it could be indicative of an unrelated condition or infection. Regarding the use of compound paracetamol and amantadine hydrochloride capsules, paracetamol is generally considered safe for managing fever, but it's important to consult your prescribing physician or dermatologist before combining it with isotretinoin. They will provide advice based on your specific health needs and medications. Amantadine is typically used for treating influenza or Parkinson's disease and is not usually recommended for fever alone. Again, please consult your healthcare provider to ensure this combination is appropriate for your situation. Always follow your doctor's recommendations and communicate any concerns or symptoms you're experiencing. Your healthcare provider can offer guidance tailored to your health profile and current medications.