How Do I Remove Restylane Irregularities in Lips 5 Months After Injection?

I had restylane injected in my upper lip 5 months ago, I can feel lumps on the inside of my lip, one small visible one where the needle went in in the middle and an irregular appearance above my lipline. I went to a new surgeon to look at it, and he said there was no product left in there and that it could be scar tissue from bad technique. How can I get back to my pre restylane state, I wasn't to concerned about it, because i thought once the material absorbed it would go away...

Doctor Answers 20

Restylane irregularities: what to do

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First of all, if one does not see it, then you do not have to do anything. Most who have irregularities feel them, but don't see them. If you have to make a real silly face to see them that you never make, again do nothing. If you do see them or just can't stand to feel them, I recommend the following:

  1. Massage the area, which will help smooth things out--this may take 2-4 weeks.
  2. The lumps can be incised and the extra Restylane removed.
  3. The lumps can be injected with hyaluronidase to dissolve some Restylane
  4. Restylane can be injected between the lumps

In most cases, option 1 is all that is needed unless extremely poor injection technique was used.


Good luck.

Boca Raton Dermatologic Surgeon
5.0 out of 5 stars 3 reviews

Incision & drainage might be necessary

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Definitely at 5 months you could have an isolated "lump" of the injected filler and for that the best and quickest solution is to "lance" it with a #18 needle and manually compress out the excess filler. This could be strongly supported if the lump was there from the beginning. Hyaluronidase works well for diffuse overinjection in the lips or other areas

Arturo Guiloff, MD
Palm Beach Gardens Plastic Surgeon
4.7 out of 5 stars 22 reviews

Hyaluronidase to dissolve restylane in the lips

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I do not have the benefit to examine you and feel the structure and firmness of your lip compared with the surgeon who saw you in consultation, but your photograph demonstrates a lip that has lost its definition and this is consistent with persistent filler. Many of my patients show Restylane or Juvederm volume effect for more than one year after treatment, but the majority have it for about 8 to 10 months.  At five months and with the appearance of your photograph, I would suggest you see a doctor and ask about the safety and appropriateness of dissolving the Restylane with hyaluronidase.

Ronald Shelton, MD
Manhattan Dermatologic Surgeon
4.9 out of 5 stars 39 reviews

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How Do I Remove Restylane Irregularities in Lips 5 Months After Injection?

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Thanks for the posted photo. I have been studying it for a half hour. Your issue are very minor, but if they disturb you than you can try   Hyaluronidase injections or Kenalog injections. These MUST be done very carefully. From MIAMI Dr. Darryl j. Blinski

Restylane can be dissolved with hyaluronidase

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One of the great things about Restylane is that it is reversable.  Restylane irregularities can be massaged away and dissolved with hyaluronidase.

Joseph A. Eviatar, MD, FACS
New York Oculoplastic Surgeon
4.7 out of 5 stars 68 reviews

Lip problem

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No question at 5 months the restalyne is all gone.  Any persistent problems relate to scar tissue formation. Whether kenalog or excision is best I could only say after an actual examination

Restylane in the lip

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The hyaluronic acid fillers such as Restylane have significant longevity in the lip.  6-9 months and longer is not an uncommon length of time for Restylane to persist.  Hyaluronidase is an enzyme which can be injected where the unwanted Restylane remains.  Very quickly and easily the residual Restylane will be dissolved.

Pamela Carr, MD
Sugar Land Dermatologic Surgeon

I would inject Hyaluronidase, then a steroid if necessary

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I would personally inject hyaluronidase into the concerning areas as Restylane can definitely last longer than 5 months in the lips. If the fullness does not resolve, then I would consider an injection of dilute steroid and aggressive massage. More than likely, your lip will return to it's pre-injection state. I have never seen "scarring" in the lip due to injections of Restylane, no matter what the technique is.
Andrew C. Campbell, M.D.
Board Certified Facial Plastic Surgeon

Andrew Campbell, MD
Milwaukee Facial Plastic Surgeon
4.7 out of 5 stars 25 reviews

Restylane for Lip Augmentation

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It is possible that you still have residual restylane in the lips, which can be causing you problem.  It is not uncommon for the product to last that long in some individuals.  If this is the case, injections of Hyaluronidase will help to dissolve the remaining Restylane.  If scar tissue is present, this may pose a more difficult dilemma.  Good Luck, Dr. Corrado

Anthony Corrado, DO
Philadelphia Facial Plastic Surgeon
4.9 out of 5 stars 43 reviews


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If you see or feel lumps, hyaluronidase injections may take care of your problem.  If they are inflamed, they can sometimes be due to a low-lying infection and may require more aggressive treatment.  You need to have an examination performed by an experienced injector to determine the best course of action.  Typically, Restylane lasts about a year in the lips but this is variable.  Best of luck.

Colin Pero, MD
Dallas Facial Plastic Surgeon
4.6 out of 5 stars 15 reviews

These answers are for educational purposes and should not be relied upon as a substitute for medical advice you may receive from your physician. If you have a medical emergency, please call 911. These answers do not constitute or initiate a patient/doctor relationship.