Thanks for your question and posting a photo. An in person evaluation would be needed to know for sure, but likely what you are referring to is a result of natural facial aging. As we age, three things in particular usually happen: decrease in the elasticity of skin, loss of facial volume (fat), and drop in the position of tissues- called ptosis. The troublesome area you may be referring to is likely a result of the last issue- the drop in position of facial tissues. It is likely due to fat that has dropped in position from your lower cheek down to outside your lips. Unfortunately, Botox or fillers are not likely to correct the problem. In order to treat tissues that have dropped, they should be repositioned back to where they should be- this requires surgery. A form of facelift may be appropriate for you. Seeing a qualified plastic surgeon will allow a full examination and a detailed, personalized treatment plan to be discussed with you. Best wishes, Rohit Jaiswal, MD Plastic Surgeon