Botox treatment for scrotum - Can anything be done to sufficiently relax scrotum?

Botox will work to relax the cremasteric muscles, which are right under the skin. But there may be a deeper cause to the tightness and discomfort. If you see a urologist, and you find out nothing deeper is going on, then 50-100 units of Botox would be enough to treat the muscle in that area. It will last about 4 months for most patients. 

Thank you for sharing your excellent question.  I would recommend first speaking with your PCP and/or urologist to discuss your testicular discomfort.  Assuming they see no other issues taking place, a neuromodulator can be injected to provide muscle relaxation.  Hope this helps.

Yes.  Botox in the scrotum is a real thing.   Neuromodulators like Botox, Xeomin, Dysport, and Jeuveau can be used to treat muscle spasms and painful muscle contractions.   However... would recommend seeing a urologist -first- to make certain that there are no other anatomic causes or etiologies of your discomfort.