I appreciate your concern. I am unaware of any evidence to suggest that Radiesse would affect the kidneys in any way. This filler contains calcium microspheres that provide support to the underlying skin structure to smooth away wrinkles and restore youthful volume. At the same time, the formulation stimulates the body to produce more collagen for additional support. This function ensures Radiesse results are both natural and long-lasting. The filler is concentrated to the treatment area and does not move through the body to impact any vital organs. If you choose to move forward with a Radiesse treatment, work with a board-certified dermatologist who has extensive experience working with this product. This will ensure your procedure is both safe and effective for you.