Ozempic vs. Wegovy vs. Mounjaro vs. Rybelsus comparison - What's best?

The data is pretty clear for this question. Tirzepatide (brand name Mounjaro) produces more weight loss than semaglutide, which is what all of those other products are.

Semaglutide (ozempic) works on one receptor, whereas Tirzepatide (Mounjaro) works on 2 receptors and is therefore more effective, with fewer side effects. Discuss this in more detail with your primary care physician before starting these medications. The main contraindication is thyroid cancer or a history of familial endocrine disorders. The drugs in general work very well if you can tolerate the GI side effects (nause, constipation, etc.).
I hope this helps.
Dr.Bruno

Hello, and thank you for your question. Ozempic and Wegovy are both Semaglutide that are injected subcutaneously once weekly. Ozempic is FDA approved for type 2 diabetes, while Wegovy is FDA approved for weight loss. Rybelsus is the oral form of semaglutide that needs to be taken daily. The subcutaneous injection tends to be a little more effective than the oral tablet. All three of these medications are GLP-1 agonists. Mounjaro is also a GLP-1 agonist, but it also works on the GIP receptor, whereas Ozempic/Wegovy/Rybelsus does not. Mounjaro tends to be a little more effective since it works on 2 receptors in the body. It os also FDA approved for type 2 diabetes, but not weight loss. I would recommend consulting with a healthcare provider to discuss which option would be best for you.

Comparing Ozempic, Wegovy, Mounjaro, and Rybelsus involves considering various factors including their efficacy, side effects, cost, and route of administration. Here's a brief comparison between them:
1. Ozempic (semaglutide): This is an injectable medication used for the management of type 2 diabetes and weight loss. It helps to control blood sugar levels and aids in weight loss by mimicking a hormone that causes feelings of fullness.
2. Wegovy (semaglutide): Like Ozempic, Wegovy is a semaglutide-based medication, but it's specifically approved for chronic weight management in adults who are overweight or obese and have at least one weight-related condition. It is also an injectable medication.
3. Rybelsus (semaglutide): Rybelsus is the oral form of semaglutide. It is used for the management of type 2 diabetes but is not specifically approved for weight loss. However, weight loss can be a side effect.
4. Mounjaro is not recognized as a medication. Perhaps there is a misunderstanding or misspelling.
In terms of which is the best, it largely depends on individual needs, medical history, and the specific health goals. All these medications have their own benefits and potential side effects. For example, some may prefer Rybelsus because it's an oral medication, while others may find Ozempic or Wegovy more effective for weight loss.

If you are interested in these medications the best place to begin is a conversation with a physician. You can visit your PCP or a provider near you. I offer a program in my practice to help my patients with their weight goals which can include semaglutide. Your physician will first need to screen you to ensure you are a good candidate for the medication.

Here is a quick summary of how GLP-1 agonists such as Ozempic, Wegovy, Mounjaro, and Rybelsus compare:
The active element in both Ozempic and Wegovy is semaglutide. While Wegovy is licensed specifically for weight loss at a higher dose, Ozempic is mostly used for diabetes.
Tirzepatide, which binds both GLP-1 and GIP receptors, is present in Mounjaro. It's more recent and has the potential to help with weight loss and diabetes.
Rybelsus: An additional semaglutide that is taken orally as opposed to intravenously. Although it's practical, managing diabetes is the main application for it.
Take into account your main objective (weight reduction vs. diabetes control), your chosen mode of administration (oral vs. injection), and any particular advice from your healthcare practitioner when selecting a GLP-1 agonist. Since each has certain advantages of its own, the ideal option will rely on your own needs.

Hi! Thank you for this terrific question! Like my heading states, no all of these medications are the same-Semaglutide is also known as Rebylsus (oral), Ozempic and Wegovy (Injectable). Liraglutide is also known as Saxenda (a daily injectable medication). Tirzepetide (Mounjaro or Zep bound) is a COMBINATION of two hormone targeting medications and works a bit differently than the others. ALL are used for glucose control primarily with a secondary finding of weight loss. Currently only Tirzepetide is approved for Obesity.Not all are the same, so to choose the right medication for you, I'd speak with your trusted physician!

The active ingredient of Ozempic and Wegovy is semaglutide. Wegovy goes to higher doses and is FDA approved for weight loss. Rybelsus is the pill form and is generally thought not to give as strong appetite suppression. Mounjaro acts on 2 receptors and I think is best reserved for people with insulin resistance or diabetes type 2.

These medications are all considered in the GLP-1 class, which mesns Glucagon like peptide agonists. They are used to treat type 2 Diabetes. Wegovy is currently FDA approved for weight loss. Rybelsus is an oral capsule taken daily. Currently being studied for weight loss approval. Ozempic is currently used for treatment of type 2 DM and weight loss. It is a once weekly injection. Ozempic has been shown to lower the risk of heart attack, stroke, and death due to heart disease. Wegovy is FDA approved for weight loss. In studies, Wegovy is more effective for weight loss. Monjauro (tirzepatide) contains dual peptides, Semaglutide and GIP. It is a weekly injection. In studies, it has been shown to be more effective for weight loss. All of these medications are mainly the peptide Semaglutide in varying doses as the active ingredient. I would recommend finding a provider familiar with the use of these medications when considering their use.

If you are a type II diabetic and actually qualify for your insurance to cover the medication for medical reasons and not weight loss, this is a question for you endocrinologist or PCP (whoever handles your DM meds). If you are wanting to utilize one of these medications for weight loss, then your options are to pay out of pocket ~$1500 per month or to find a place where you can get a compounded version and cash pay. In my office I offer a weight loss program with Semiglutide (a compounded version of Ozempic with B12). We do not offer any other version. The cost starts at $450 per month and goes up from there depending on dose (price increases as the dose of medication gets higher). So it is cost effective to find the lowest dose that will work for your body.