Unfortunately, without knowing what type of filler was used it is difficult to comment in all but the most general terms. If a hyaluronic acid-based filler was used (hopefully), then the filler lumps and bumps may be dissolved with hyaluronidase. If permanent fillers, such as Bellafill or silicone, were used, the nodules will be much harder to treat, since there is no analogous dissolving enzyme for these types of injectables. Sorry. Surgical removal of permanent filler-related nodules and granulomas is one option, but this typically leaves scars and potential lip distortion. I have success with these using a combination of subcision to break up the lumps, as well as the accompanying injection of triamcinolone acetonide, an antiinflammatory agent, along with hyaluronidase for helping the antifinflammatory to disperse better through the unwanted lumps. Make sure that you consult with a board certified aesthetic physician. Best of luck to you.