Hashimotos and fillers / hyaluronic acid. What is the least invasive and most tolerated substance?

I recommend treatment of the nasolabial folds with a hyaluronic acid based filler like Restylane Refyne or Restylane Defyne. 

Thanks for your question.  Hyaluronic acid based fillers ( Juvederm and Resylane family of products) are the way to go.   These fillers are dissolvable in the rare event something goes wrong.  Go to an experienced board certified dermatologist or plastic surgeon.  Go for it, fillers are great! Lana Long MD 

HA fillers are safe in autoimmune conditions. I perform at LEAST one to two a week on complex cases like GVHD and autoimmune conditions that can present on the skin - like lupus. Yours, with respect, is not a complex case. For full explanation see a dermatologist or plastics as most would have read the latest articles on this common topic. Dr Davin Lim, Aesthetic dermatologist. Brisbane. Australia.