have taken it 2 times 10 mg,6months / 20 mg 3months. My skin was wonderful but it's back.I would like to know the risks associated with taking it again. I have IBS & history of depression would take it again be dangerous for my long-term health? Could it aggravate my stomach issues and my mental health issues, it there something else I should try something else first( try doxycycline for 3 months but didn't work) my current medications: Vyvanse, Synthroid, Effexor, dexilant.