There are hundreds of different HPV strains and many do not cause any clinical manifestations. There are HPV subtypes that can manifest as "common" warts in any part of the body; and there are subtypes types that can cause genital warts and/or specific skin, oral/laryngeal, lung, colorectal, or anogenital cancers. Transmission can be either cutaneous (abrasion of the skin) or mucosal (sexually transmitted). However, it has been widely accepted that HPVs are not disseminated to other sites by blood, i.e., there is no viremic phase in the course of HPV infection. However, the following study was able to show that HPV DNA (subtype 16) was present in PRBC's, sera and plasma of HPV-infected individuals. Thus, in theory, HPV could be disseminated through blood products. PRF has a higher concentration of growth factors and platelets in the plasma. There needs to be more extensive studies to show that HPV can be easily disseminated to other sites in the body through blood; thus, in theory it could happen. One's risk for "spread" and clinical manifestation of the infection to other parts of the body may be influenced by the HPV subtype the person is confirmed to have. The risk is likely very low (but not zero) due to the historical acceptance that dissemination of HPV to other parts of the body does not happen by blood. The following study is the one I mention in my response. A person with HPV should have a thorough discussion with her/his provider before engaging in PRF. Despite the very low risk potential with PRF, as with any procedure, the risk is never zero.