Is Plaquenil and/or Xarelto medications likely to make me photosensitive? They were flagged during hair removal.

Plaquenil makes you at higher risk for pigment changes in areas treated with the laser.  I would be reluctant to treat your face while you are on this medication, even if you have no problems with underarm treatment, because different areas of the body react differently to the laser.  You could even do fine with one facial treatment, then have problems the next.  You might try speaking with the physician who precribed Plaquenil for you about using a different drug.  Without knowing your medical history, I can't really speak to that, but don't be afraid to ask questions of the the doctors you are seeing for both your medical and cosmetic issues!

As to Xarelto, the issue here is bruising following the treatment.  It is possible to have laser treatments while on blood thinner, as long as you understand that you may develop bruising afterward.