Syringoma persist after CO2 laser?

A bit hard to answer without a photo; however, I will say that it is not uncommon to require a couple of treatments with CO2 resurfacing.  This is an excellent modality to treat syringomas - but they can also be stubborn sometimes.  Often times also it becomes hard to tell where all of the lesions are with the local anesthetic present.  Bottom line you may need more but this is expected in my opinion.

Yes some syringomas persist after laser. This depends on the DEPTH of the syringoma and the penetration of lasers. I use CO2 in some patients, or erbium lasers in others. If one goes too deep 'chasing' syringomas in this area, scarring can results. I have seen a few cases done in Asia where by the doctor tries to remove every syringoma, only to give scarring. I tell my patients that I may not get every lesion, and that recurrence is possible. Wishing you well, Dr Davin Lim, Brisbane. Australia.