Major Fat Atrophy Around the Eyes on Lash Line: What to Do?

  I agree with the other physician who responded.  It is highly unlikely that Latisse can cause fat atrophy as there is no fat in the area where you are supposed to apply the medication.  Either see an oculoplastic surgeon for your concerns (recommended) OR post photographs for a better online advice.  Good luck!

I have seen no evidence that Latisse causes removal of fat around the eye.  You use Latisse on the upper lid so it doesn’t get into the eye.  But in most patients there will be lower eyelash growth, just from normal blinking and from applying the Latisse at night when the eye was closed.  But it may be that there is a pigmentation, which can be caused by Latisse and which may change the appearance of the lower lid making it look sunken.  In this situation, I would stop Latisse, and the pigmentation should go away gradually over several months.

There is definitely an association of Latisse with localized fat atrophy. At the UIC Eye & Ear Infirmary, we have a series of these patients. This is most obvious in patients with unilateral Latisee use and unilateral fat loss. Google Latisse and fat loss to see other reports. There is fat in the area -- pre-septal fat as well as orbital fat. How frequent this complication occurs and how severe or reversible is not established. But it is definitely real.