Dear Ms Walker;This is a very good question with a complex answer. If your goal is to have results in one treatment, you have a large volume of fat to be removed, and you don't mind having downtime, aftercare, the possibility of ridging, and risks of surgery and anesthesia, liposuction is for you. With regard to the two noninvasive options that provide permanent removal of fat, 24 to 28% of the fat in the treated area will be removed in a single treatment. If you have multiple areas that need to be treated you will need to have more than one treatment either on the same day are on different days. You are unlikely to have downtime. Unless you have a very large volume of fat in multiple areas to be reduced, the noninvasive options are less expensive than liposuction. If these factors appeal to you, then one of the noninvasive options is for you. Of these, CoolSculpting is still the gold standard, for several reasons. Firstly, it's been around since 2009, and the efficacy and side effects are well understood. Secondly for most people it is not uncomfortable to have the procedure performed, whereas in my experience some patients relate that SculpSure is either painful or in some cases intolerable. Thirdly, and this is not a major difference, although each SculpSure treatment takes only 25 minutes to be completed, the treated area itself is about the size of a pack of cards, and it takes more than eight of these SculpSure areas to add up to the size of the area treated with one collSculpting CoolSmooth applicator, and more than 10 of these SculpSure areas to add up to the size of the area treated with one CoolSculpting CoolMax applicator. Since four of these areas can be treated at once, two on each side of the body, you would need more than two SculpSure cycles of four treatment areas each to equal one treatment with a CoolSmooth applicator, and three cycles of SculpSure to treat more than the area treated by one CoolMax applicator. Also, although there is not a great difference in efficacy, studies with SculpSure have reported up to 24% fat reduction, whereas with a post-treatment massage, CoolSculpting delivers a 28% reduction of fat in the treated area.SculpSure could be preferable if one has a cold-induced disorder such as circulating cold agglutinins due to chronic active hepatitis, or possibly a history of Raynaud's disease or chilblains. I hope this information is helpful to you. All the best, Dr. Clark