I have no hard evidence that prednisone affects Coolsculpting, but I would say that it probably does. Steroids may protect fat cells that otherwise would have been killed. It also prevents the inflammatory response which carries out the removal of the dead fat cells. My vote is that Coolsculpting results are negatively affected by steroids.
The question is why you are prednisone. Prednisone itself is not a contraindication for coolsculpting but it is unclear to me what underlying condition you are being treating for. Perhaps you can post the entire question. Best, Dr. Green