Polynucleotide injections, like other facial injectables, carry certain risks, but the risk of blindness is typically associated with dermal fillers, particularly when they are accidentally injected into or compress a blood vessel that supplies the eye. Polynucleotides, often used for skin rejuvenation, generally have a different mechanism of action and are less likely to pose this specific risk compared to fillers. However, it is crucial to have any injectable procedure performed by a qualified and experienced healthcare professional who understands facial anatomy and can minimize risks. Always discuss potential risks and benefits with your provider before proceeding with any treatment.