Will I get a purging period if I switch from Epiduo to Tretinoin?

Question

Hi, I have hormonal acne that is being very stubborn. I am currently taking Epiduo which has helped but I am thinking of switching to Tretinoin. I was wondering if I will still get a purging period when I start this new medication as I am already taking a retinoid? Thankyou!

Anna Chacon, MD, FAAD · Answer

When switching from Epiduo, which contains adapalene (a type of retinoid) and benzoyl peroxide, to tretinoin, it's possible to experience a purging period, although it might not be as pronounced as starting a retinoid for the first time. Here's why and what to expect:

Understanding Purging:

Purging occurs when retinoids accelerate the turnover of skin cells, bringing underlying clogged pores and acne to the surface more quickly. This can temporarily worsen acne before it gets better.
Switching Retinoids:

Since Epiduo already contains adapalene, your skin is somewhat accustomed to retinoid effects. However, tretinoin is often considered more potent, which might still lead to a purging phase as your skin adjusts to the new formulation.
Duration of Purging:

If purging occurs, it typically lasts for several weeks, often around 4 to 6 weeks, though this can vary based on individual skin responses.
Minimizing Purging Effects:

Gradually introduce tretinoin by starting with a lower concentration or using it less frequently, then slowly increasing as tolerated.
Maintain a gentle skincare routine, avoiding harsh cleansers or exfoliants that can exacerbate irritation.
Consult Your Dermatologist:

Discuss your plans with your dermatologist. They can provide personalized advice, possibly adjusting the concentration of tretinoin or suggesting supportive skincare products to ease the transition.
By transitioning carefully and under professional guidance, you can manage potential purging and continue working toward clearer skin.

Will I get a purging period if I switch from Epiduo to Tretinoin?

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