Hi and thank you for your question. I am not an infectious disease specialist of course, but will try to contribute a little. MRSA is just a drug resistant form of a Staph. bacteria that is normally found on everyone's skin all of the time. In general, it not more aggressive than the garden variety Staph, its just that its harder to get rid of once you have an infection. Probably the more important issue would be to determine if you have any immunocompromise. Do you have diabetes? Are you taking steroids? Are you slow to heal from cuts, etc.? Without any scientific evidence to support my suggestion, perhaps the most cautious way to move forward (other than not moving forward) would be to not only clean your skin in the area of anticipated injections, but to disinfect the area with betadine or similar surgical prep. Essentially, act as if it were a real surgery and inject in a sterile field rather than a "clean" field which is what we would normally do. As you imply, using a shorter lasting filler is probably a good idea (hyaluronic acid). I hope this helps a little and be well.