Deep lines in the upper lip are caused in some patients by the strucure of their bone and teeth, excessive pursing during speech (some people use these muscles more in a pursed fashion when pronouncing certain letters), pursing during smoking, chronic sun exposure and other causes. Fillers last for about six months in this area, sometimes longer, but not as long as compared to the smile folds because of the large amount of movement of the lip muscles. The most aggressive resurfacing technique can help reduce the lines and their depth but you will still have them to some extent because the muscle will keep pursing the skin into creases. Small amounts of botulinum toxin can minimize this pursing but can lengthen the lip and cause problems with speech and eating/drinking. There is no treatment that will permanently eradicate these lines. Permanent fillers such as silicone would be used as an off-label, nonFDA approved use, and there might be a reaction in the future such as lumps that would have to be surgically removed. Resurfacing with a Fraxel Repair laser, dermabrasion or the original carbon dioxide laser can be used with improvement, but you have to realize you will still have some lines, and you may develop a lighter skin color in the treated area.