Testosterone Replacement Therapy (TRT) is commonly used for treating hypogonadism, a condition where the body does not produce enough testosterone. Accutane, or isotretinoin, is a medication used to treat severe acne. There is no direct contraindication to using both Accutane and TRT at the same time. However, it's important to note that both of these treatments can have side effects. For instance, TRT may potentially worsen acne in some individuals, and Accutane can cause dry skin, joint pain, and in rare cases, mood changes and liver issues. As to whether it's common for people on TRT to use Accutane, it's not something that can be generalized. The decision to prescribe Accutane would depend on the severity of the acne and the individual's response to other treatments. As always, it's crucial to discuss your medical history, current medications, and potential side effects with your healthcare provider before starting any new treatment.