Hello okthen9, thank you for your question regarding sudden lipedema and EDS-like connective tissue issues after HRT and if a knee lift or mini thigh lift is needed. Thank you for history and pictures. If you are medically healthy, you could have a mini thigh lift or knee lift. You will need to be cleared by your internist, and blood tests, an EKG, and a chest X-ray will have to be done. If you pass those tests, you could have a mini thigh lift or knee lift. During a mini thigh lift or knee lift, an incision is made on the inner portion of the thigh. The scar is placed like the inseam on your pair of jeans. The scar length depends on the excess skin and fat that bothers you and how long a scar you allow the plastic surgeon to create. A mini thigh lift or knee lift is performed under general anesthesia. A mini thigh or knee lift takes approximately 3 to 4 hours to complete. Drains are usually required and are typically removed after about 10 to 14 days. A compression garment will need to be worn for about six weeks. In conclusion, if your knee is bothering you and you are medically healthy, you can proceed with a mini thigh lift or knee lift. Good luck. I hope that I have answered your questions regarding the thigh reduction. If you have any more questions regarding the thigh lift, thigh reduction, vertical thigh lift, medial thigh lift, spiral thigh lift, crescent thigh lift, or thigh lipo, contact an experienced plastic surgeon. Please seek an experienced, board-certified plastic surgeon with significant experience performing thigh lifts. Do your research. Make sure your chosen plastic surgeon has performed at least 100 thigh lifts. Make sure they have the before-and-after pictures to prove it. Carefully examine their before-and-after pictures and check their reviews on RealSelf. Sincerely, Dr. Katzen, MD, MBA (President of the American Society of Bariatric Surgeons; Certified by the American Board of Plastic Surgery; Fellow of the International Society of Aesthetic Plastic Surgery, American College of Surgery, International College of Surgery, and American Board of Metabolic and Bariatric Surgery; and member of the American Society of Plastic Surgery, American Academy of Cosmetic Surgery, RealSelf Hall of Fame, and RealSelf Doctor Advisory Board for Medical Review and Consumer Panel.) I hope that I have answered your questions regarding the thigh reduction. If you have any more questions regarding the thigh lift, thigh reduction, vertical thigh lift, medial thigh lift, spiral thigh lift, crescent thigh lift, or thigh lipo, contact an experienced plastic surgeon. Please seek an experienced, board-certified plastic surgeon with significant experience performing thigh lifts. Do your research. Make sure your chosen plastic surgeon has performed at least 100 thigh lifts. Make sure they have the before-and-after pictures to prove it. Carefully examine their before-and-after pictures and check their reviews on RealSelf. Sincerely, Dr. Katzen, MD, MBA (President of the American Society of Bariatric Surgeons; Certified by the American Board of Plastic Surgery; Fellow of the International Society of Aesthetic Plastic Surgery, American College of Surgery, International College of Surgery, and American Board of Metabolic and Bariatric Surgery; and member of the American Society of Plastic Surgery, American Academy of Cosmetic Surgery, RealSelf Hall of Fame, and RealSelf Doctor Advisory Board for Medical Review and Consumer Panel.)