Is Itching Following Sclerotherapy a Sign of an Allergic Reaction?

Itching is common immediately after a sclerotherapy treatment. Which is why we apply a potent topical corticosteroid immediately after treatment under the graduated compression stocking. Though itching after sclerotherapy may be a sign of an allergic reaction, there are also several other reasons for what you are experiencing. If you are overly concerned, I'd recommend seeking help from your treating physician or get a second opinion from an experienced cosmetic dermatologist specializing in sclerotherapy. Because the natural reaction of the body upon injection of the sclerosing agent may be to release histamine, itching can ensue. If you are experiencing other symptoms like swelling, discoloration, or severe discomfort, it's important to seek help. As a double board certified dermatologist and cosmetic surgeon, I would suggest that you make sure you speak with a professional.

It is common to have itching at the injections sites after sclerotherapy treatment.  Applying a topical hydrocortisone 1% cream may be helpful.  The itching should subside shortly.

Local itching at sites where sclerotherapy was performed can be common after the procedure.  As the point of the procedure is to induce a local inflammatory reaction in the vessel, that can result in histamine release, which causes us to itch. This is typically why in our practice we apply a topical steroid to the legs immediately after sclerotherapy, to mitigate this reaction.  Although rare, if you are having itching beyond the areas of injection (rest of your body), you should notify your treating physician as this may be a sign of an allergic reaction, especially if it is accompanied by a rash.

Itching has been described with sclerotherapy but I rarely see that as a complaint from my patients. An allergic reaction that is significant would cause a lot of other symptoms which warrants immediate treatment, typically within an hour after sclerotherapy. Otherwise, the itching can be treated with topical steroids and benadryl and may be a reaction to the sclerosant solution, a reaction to tape or the ace bandages or stockings ... consult your physician for guidance .. 

Temporary itching and usually localized to the areas treated by sclerotherapy especially around the ankles is common and not a sign of an allergy.  This reaction is due to the localized inflammation and irritation caused by the sclerosing solution.  A topical steroid ointment or even aloe usually resolves this.  It is possible, although most unusual , to have a true allergic reaction to the sclerosing solution used and would present with true allergic symptoms.