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Isotretinoin is a powerful medication used primarily to treat severe acne. While it is effective, it can have a number of side effects. Hair thinning or hair loss are reported side effects of Isotretinoin. However, it is important to note that the association between isotretinoin use and alopecia areata, specifically, is not well established. Alopecia areata is generally thought to be an autoimmune condition, which can be triggered by a variety of factors.However, each patient is unique and responses to medication can vary. If a patient is predisposed to alopecia areata and is experiencing hair loss while on isotretinoin, it would be advisable to discuss this with the prescribing physician. They can provide guidance on whether the medication might be contributing to the condition, or if other treatments or strategies are advisable.