Is the cumulative dose or treat to clear more effective method for isotretinoin?

The cumulative dose approach is the traditional method of prescribing isotretinoin. It suggests a total dose of 120-150 mg/kg over a treatment duration of 20 weeks. Studies have shown this approach to be effective in long-term remission of acne.
The treat-to-clear method involves treating the patient until their acne has completely cleared, regardless of the total cumulative dose. This method can be beneficial for patients who may not tolerate the side effects of higher doses of isotretinoin.
Both methods have been shown to be effective, and the choice between them often depends on individual patient factors, such as the severity of acne, the patient's tolerance of the medication, and their response to treatment.