Can I Get Hyaluronidase 1 1/2 Years After a Restylane Treatment?

Hi, I had Restylane injected into my lips 1 1/2 years ago and it still has not completely dissolved. Is it too late to get hyaluronidase injections to dissolve the remaining filler? My lips look uneven, but I worry about further complicating things. What should I do? Thank you

Doctor Answers 12

Hyaluronic acid fillers, Juvederm and Restylane can be dissolved by hyaluronidase

However, after about a year or so most of the filler is gone. If there is any residual filler, there may be further improvement. What's good about hyaluronidase is that it won't harm your natural tissue. I have found that some patients get improvement in areas that have been over-injected even 2 years later. Since there is little downside other than a few needle sticks, it can't "hurt" to try. If fullness or lumpiness persists, scar tissue and natural collagen buildup can be seen in areas of injection, especially if it has been injected numerous times.

New York Facial Plastic Surgeon
4.9 out of 5 stars 127 reviews

Can I Get Hyaluronidase 1 1/2 Years After a Restylane Treatment?

  You can but it's highly unlikely that any of the Restylane is still present 1 1/2 years after it was injected so there's be nothing for it to dissolve.  Are you certain that the filler injected into your lips was Restylane and not a permenent filler?  Be sure that the MD, you select, for your Lip Augmentation using fillers understands and follows the proper aesthetics of facial beauty (and lip proportion) for the creation of naturally, more attractive lips and face.

Francis R. Palmer, III, MD
Beverly Hills Facial Plastic Surgeon
4.7 out of 5 stars 26 reviews

Hyaluronidase 18 months after Restylane

It would be extremely unusual for you to have residual Restylane in your lips after 18 months. I agree that you should check whether you had Restylane as opposed to Perlane, Juvaderm, Radiesse, etc. You should return to your treating physician to inquire and also to take a look at your pre-treatment photos to see whether your lips were even to begin with. Hyaluronidase can be used long after a treatment.

Robert L. Kraft, MD, FACS
New York Plastic Surgeon
5.0 out of 5 stars 42 reviews


Yes, if there is still product and it was an HA product such as Juvederm or Restylane then the hyaluronidase injection will help.  However, 18 months after injection, most of the product should be gone.  However, it is always worth a try.


Good Luck.

David Shafer, MD
New York Plastic Surgeon
4.9 out of 5 stars 77 reviews


There is no problem getting hyaluronidase at this late date.  I agree that it would be unusual for Restylane to still be there, but not impossible.  Double check that you did indeed get Restylane.  I have seen Juvederm last this long much more often than Restylane. It can also be dissolved by hyaluronidase.  

Jacqueline Calkin, MD
Sacramento Dermatologic Surgeon
5.0 out of 5 stars 4 reviews

Restylane in lips

Restylane should not be in your lips after 18 months. Your lips move so much that if usually only lasts 6 months. I'd see physician for an evaluation, but if you DO have Restylane in there you can get hyaluronidase - it works at any point to dissolve HA. Your physician will need to use much less than normal since you should only have a small amount (if ANY!) of Restylane left!

F. Victor Rueckl, MD
Las Vegas Dermatologist
4.6 out of 5 stars 17 reviews

Hyaluronidase after Restylane

You could return to your injector for assessment to see if hyaluronidase would help dissolve the Restylane.  It is worth a try if you do not like your lips.  You could also discuss adding more filler with an experienced injector to even out your lips.

Martie Gidon, MD, FRCPC
Toronto Dermatologist
5.0 out of 5 stars 22 reviews

Hyaluronidase for fillers

Hyaluronidase can certainly be injected at any point into the skin, but realistically speaking, the filler is typically gone by 6 months in the lip area so the benefits here would be modest at best.

Benjamin Barankin, MD, FRCPC
Toronto Dermatologic Surgeon
4.8 out of 5 stars 53 reviews

Uneven lips

You could get an injection into the area that is too big.I don't think it will matter.but most of the time the restylene should be gone but soemhow it lingers a little longer in you.

Robert Brueck, MD
Fort Myers Plastic Surgeon
4.9 out of 5 stars 65 reviews

Hyaluronidase - 1 1/2 year after treatment?

Well, you can have hyaluronidase injected but I don't think it will do much.  Most or all of the HA is probably gone by now (absorbed by your body) and I don't think you can expect the results to be reverse.  Anything you still have is more likely swelling or even some scar tissue rather than the HA itself; and neither of those would be reversed.  There are few downsides to having hyaluronidase injected, but I doubt it will help you.

Sorry about that,

Dr. E

Alan M. Engler, MD, FACS
New York Plastic Surgeon
5.0 out of 5 stars 125 reviews

These answers are for educational purposes and should not be relied upon as a substitute for medical advice you may receive from your physician. If you have a medical emergency, please call 911. These answers do not constitute or initiate a patient/doctor relationship.