Will Hyalurindase Help with Removing Silicone from Lips?

Question

I have had silicone injection in my top lip over 10 years ago. I have always regretted it and hated how it changed my face.  I have had a few kenalog injections that take the puffiness down but does not last long.  My Dr suggested before surgery to try injecting Hyalurindase.  I have been reading about its effects on helping with fillers etc. but not sure how it will help with silicone.  Any feedback or help on this would be tremendous help.

Raffy Karamanoukian, MD, FACS · Answer

I have successfully removed silicone in the lips from many women with enormous success. The treatment is usually outpatient and can restore normal contours to the lips. Raffy Karamanoukian Los Angeles

Jeffrey J. Roth, MD, FACS · Answer

Hyaluronidase will desolve hyaluronic acid fillers. (i.e.: Restylane and Juvederm). Silicone is not hyaluronic acid based and therefore it won't work for that. Silicone is thought to be a permanent filler that does not have a chemical to dissolve it. Best to see a board certified plastic surgeon or otolaryngologist, (ENT). They will guide you through the process that might include excision.

Ron Shelton, MD · Answer

Hyaluronidase is an enzyme that degrades hyaluronic acid which is contained in Restylane and Juvederm. Injectable silicone does not contain this acid so it will not be affected by hyaluronidase.

Richard Baxter, MD · Answer

Although I have seen some good long-term results from silicone injections into lips, I think that for most people permanent injectable materials in the lips will cause problems at some point. Hyaluronidase is an enzyme that breaks down hyaluronic acid, the building block for Restylane, Juvederm, and Perlane. Kenalog is a steroid similar to cortisone, so it helps with inflammation and swelling but also won't affect the silicone. It may require surgical removal if it continues to be a problem. Wish I had better news.

Martie Gidon, MD, FRCPC, FAAD · Answer

Hyaluronidase will only dissolve hyaluronic acid fillers such as Restylane and Juvederm.  It will have no effect on silicone.

Steven Wallach, MD · Answer

Silcone in the lips is a permanent product that is very difficult to remove. Hyaluronidase which can be used to dissolve restylane or juvadern will have no affect on silicone.

Darryl J. Blinski, MD · Answer

Absolutely NO! Do not inject it into a silicone injected lip! The only way is a surgery to TRY and excise the silicone, very difficult if not impossible. 
From MIAMI Dr. B

Chad L. Prather, MD · Answer

Unfortunately, hyaluronidase will not remove permanent fillers such as silicone from the lips or other areas of injection.  Silicone is a permanent product that can only be surgically removed, which can be extremely difficult with injection of the liquid silicone products.  Steroids really are the best bet.
Hyaluronidase enzymatically breaks up hyaluronic acid fillers like Juvederm and Restylane, but not silicone.  However, I also don't think it will cause damage to the lips... it just won't dissolve the silicone.

Peter A. Aldea, MD · Answer

Silicone is a permanent filler which even of high purity medical grade is associated with a patient dependent inflammatory and scarring process. It will NOT be erased by Hyaluronidase which is an enzyme which will specifically break up Hyaluronic Acid fillers (such as Juvederm,Perlane and Restylane). Use of steroid injections may relieve some of the swelling but will not remove or in any way "de-activate" the silicone.

Charles Perry, MD · Answer

In general the Hyaluronidase has not worked in reducing the silicone in my experience, on some occasions it can soften the scar tissue surrounding the silicone beads in the lips. It is helpful to let others know of your experience as more and more physicians and nurses are using silicone for lip enhancement and while it looks good for a time in general your experience is common that after ten years it gets hard and swollen. Silicone can be removed surgically.

Will Hyalurindase Help with Removing Silicone from Lips?

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