Are You Supposed to Massage Hyaluronidase to Remove Filler?

I just got hyaluronidase injected into my lips because the restylane made me look like a duck. i've heard that it works instantly. am I supposed to notice something right away? Should i massage my lips to ensure that it spreads throughout and gets rid of it?

Doctor Answers 5

Hyaluronidase should be massaged after injection

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I have patients massage after hyaluronidase for two reasons. One is to disperse the hyaluronidase a little, and cover the area of unwanted HA injection while feathering into the surrounding tissue. Two, it helps the unwanted HA break down and resorb. You should know that hyaluronidase works very quickly, often times within a 1-3 day span, so if you don't see resolution, you should check back with your injectionist.

It also can induce a little swelling of it's own, so give it some time. Finally keep in mind that the speed and total effect of hyaluronidase is based on dose. If things are not dissolving quickly enough, you might just need more hyaluronidase.

Madison Facial Plastic Surgeon
4.7 out of 5 stars 15 reviews

Massage after Amphidase is recommended

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I think its a good idea to massage your lips after Hyaluronidase (Amphidase) treatment. It should help the product dissolve faster. Your lips should resume their normal contour after a few weeks. Good luck!

Hyaluronidase Does Not Need Massaging

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This material breaks through the connective tissues and does not need any massaging. It takes 2 to 3 days to work. If you have not seen the results in one week, then you should go back for more hyaluronidase.


Tanveer Janjua, MD
Bedminster Facial Plastic Surgeon
5.0 out of 5 stars 126 reviews

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Hyaluronidase and Restylane

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If the hyaluronidase is not made to migrate to distant areas (which would dilute its effectiveness in the intended area) then gentle massage could be expected to hasten the dissolution of the hyaluronic acid Restylane my increasing the surface area of the filler exposed to the enzyme. You should check with your physician before doing this.

Ronald Shelton, MD
Manhattan Dermatologic Surgeon
4.9 out of 5 stars 39 reviews

Hyaluronidase to Dissolve Fillers (Restylane, Juvederm), Does Massage Help?

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Hi Ar,

As my Mom used to say, "It can't hurt".

Hyaluronidase should be injected into the hyaluronic acid (Juvederm, Restylane) to be most effective. If you do not see the results you desire, return for more injections. I cannot imagine that gentle massage would cause any problems, and it may help a little.

Good luck, be well, and I hope that your lips return to a satisfactory state quickly.

Dr. P

Michael A. Persky, MD
Encino Facial Plastic Surgeon
4.8 out of 5 stars 39 reviews

These answers are for educational purposes and should not be relied upon as a substitute for medical advice you may receive from your physician. If you have a medical emergency, please call 911. These answers do not constitute or initiate a patient/doctor relationship.