Can Too High a Dose of Sprionolactone Make Acne Worse?

I am a 22 year old female who has been struggling with acne since the age of 19. I have been on Spironolactone 150mg since July 2011 and recently my acne as gotten worse. My doctor has risen the dose to 200mg a day and my acne just seems to be getting worse if anything. I haven't had a period since June and it's now September. It feels like I"m in a perpetual state of PMS. I can't take BC with estrogen or else I'd try that. Thoughts?

Doctor Answers 2

Talk with your doctor!

You need to talk.  I think spironolactone really blunts the androgenic effects of acne, but if you are not getting better it is time to talk again. Blood work and hormone assessment may be in order   I usually find 50 mg twice a day works for most women so you are on a relatively high dose.  Time to talk!

Los Gatos Dermatologic Surgeon
5.0 out of 5 stars 11 reviews

Acne help

You need a really great board certified dermatologist.  Firstly, you should consider having some blood work done and check your hormone levels.  Secondly, you need an amazing acne program, clearly the spiro isn't working for you.  There are so many other options, including antibiotics, lasers, lights, creams, peels, acutane, etc etc.  Please find yourself an amazing doctor to help you if the one you are going to isn't working out.  Don't lose hope, there are so many effective treatments for adult acne. 

Rebecca Baxt, MD
Paramus Dermatologic Surgeon
4.8 out of 5 stars 27 reviews

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