I am a 22 year old female who has been struggling with acne since the age of 19. I have been on Spironolactone 150mg since July 2011 and recently my acne as gotten worse. My doctor has risen the dose to 200mg a day and my acne just seems to be getting worse if anything. I haven't had a period since June and it's now September. It feels like I"m in a perpetual state of PMS. I can't take BC with estrogen or else I'd try that. Thoughts?