Can Too High a Dose of Sprionolactone Make Acne Worse?

You need a really great board certified dermatologist.  Firstly, you should consider having some blood work done and check your hormone levels.  Secondly, you need an amazing acne program, clearly the spiro isn't working for you.  There are so many other options, including antibiotics, lasers, lights, creams, peels, acutane, etc etc.  Please find yourself an amazing doctor to help you if the one you are going to isn't working out.  Don't lose hope, there are so many effective treatments for adult acne. 

You need to talk.  I think spironolactone really blunts the androgenic effects of acne, but if you are not getting better it is time to talk again. Blood work and hormone assessment may be in order   I usually find 50 mg twice a day works for most women so you are on a relatively high dose.  Time to talk!