What can help these holes? (Photo)

From your photo, these appear to be atrophic acne scars, which are depressions left behind after inflammation damages the collagen that once supported the skin. The encouraging news is that there are treatments that can improve them, but there isn't one procedure that simply "pushes" them to the surface.

The best approach depends on the type of scars you have:

If the scars are tethered (held down by fibrous bands), subcision is often one of the most effective treatments. This procedure releases the scar from the tissue underneath, allowing it to lift naturally over time.
If the scars have sharply defined edges (such as ice pick or some boxcar scars), treatments like TCA CROSS can stimulate collagen within the scar itself and gradually make it shallower.
For broader, rolling scars, fractional laser resurfacing or microneedling with radiofrequency can help remodel collagen and smooth the skin over multiple sessions.
In selected cases, small amounts of hyaluronic acid filler can be placed beneath individual depressed scars to provide immediate improvement while the skin continues to remodel.

One thing I always emphasize is that acne scar treatment is usually a combination process. Most patients benefit from two or more complementary procedures rather than relying on a single treatment. That combination is what often produces the most noticeable improvement.

It's also important to have realistic expectations. Deep acne scars can usually be significantly softened, but they rarely disappear completely. My goal is to make them much less noticeable in everyday lighting rather than striving for perfectly smooth skin.

Looking at your photo, I think there is definitely room for improvement. A treatment plan focused on releasing tethered scars, stimulating new collagen, and resurfacing the skin would likely provide more benefit than trying to rely on one procedure alone.

While these scars can be frustrating, they are among the skin concerns where gradual, staged treatment often leads to meaningful improvement over time. Patience is key, because collagen remodeling continues for several months after each procedure, and the best results are usually achieved progressively rather than all at once.

Subcision, which I have been performing since 1995, has a several decades' long track record for safely and effectively elevating all kinds of skin indentations and atrophic, depressed scars from all causes and in all skin types. You would be wise to consult with a board certified cosmetic dermatologist subcision expert. Hope this helps and best of luck.

Your acne scars can be treated and improved my a combination treatment of RF Microneedling like Genius and Fraxel 1540 . Give at least 4 sessions and you will be happy and they will look much smoother.Acne scars are not easy but start with combination lasers for best result. If you just do one, you may not be as happy.
Best, Dr.Anna Avaliani

Typical acne cars like yours can be easily treated with a multitude of hyaluronic acid fillers. Simply find a reputable Plastic Surgeon or Dermatologist for such a job. I hope this helps and good luck from New York City Plastic Surgery.