A lipoma is not related to varicose veins but the first thing is to make sure that it's a lipoma and not somehow an extension of the veins. You should therefore have consultations with, first, a vascular specialist to outline the treatment for the veins (you'll undoubtedly need tests such as a Doppler ultrasound of the veins to see the degree of valvular incompetence) and, secondarily, a plastic surgeon to discuss treatment of the lipoma.While lipoma removal itself is not necessarily a "large" procedure it is nevertheless a surgical procedure and has to be treated as such. That means that if it is very large (tennis ball size would be large) then you may need a drain to adequate evacuate the space once it's removed or, at least, have that area monitored carefully post-op to make sure that fluid does not accumulate. Activity should be restricted for about three weeks post-op or until your surgeon gives you the go-ahead, and I advise my patients to avoid taking anti-platelet medications (such as aspirin and ibuprofen) for at least 3 weeks before and after surgery (that duration is not universally agreed-upon).I would probably not want to remove the lipoma at the same time that you're having the veins done but that's a decision you and your doctors can make after having the conditions evaluated.I hope that this helps and good luck,Dr. Alan EnglerMember of RealSelf100