I have a great deal of personal experience with the use of both wrinkle relaxers, such as Botox (which I have been injecting for aesthetic purposes since 1991), and with fillers (which I have been injecting since 1982, using the original Zyderm I collagen filler). There is absolutely no contraindication or medical reason against injecting Botox (or Dysport or Xeomin, for that matter) during the same treatment session, even when both are injected within the same treatment region. So, clearly there is little likelihood of any problem when the two are injected at separate and distinct treatment sites, as in your case.However, were your doctor to inject Botox and fillers within the same site, it is best to inject the filler first and then the Botox. When performed in the opposite order, there is some chance of accidentally dispersing the Botox outside of the desired treatment region as the filler is injected and then massaged into place. On the other hand, if you and your physician should decide to separate the treatment sessions, it is best to perform the Botox first and at the subsequent vist the filler, since the reduction in movement that is achieved by the prior Botox injection will permit more accurate placement of the filler and a diminished likelihood of premature mechanical breakdown of the filler due to mimetic facial movements. (As an aside, when filler and Botox are combined at one treatment site, the results typically last significantly longer than when either of the aforementioned are used alone).