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Really depends on your skin sensitivities and the depth of rolling. From a safety point of view, start with say 0.25 mm roller, test patch the retinol and go from there. Derma rollers, much like DermaPen and SkinPen is a form of Collagen Induction Therapy or CIT. Rollers have needles of varying depth, typically ranging from 0.2 mm to 3mm. DermaRolling technique is very important, not only for results, but most importantly patient safety. Important factors to consider include clinical indication, size of needles, number of passes, area treated, counter traction, pressure of rolling, number of needles, and many other factors. With proper technique, dermal remodelling can be achieved with needles less than 0.2 mm. With large diameter rollers and needle depth longer than 0.25 mm, micro-tears can occur. This can lead to scarring- hence why the majority of specialists will caution at home use or DIY needling for devices more than 0.25 mm. Performed safely with correct depth and technique, DermaRollers can give a modest improvement in some forms of acne scarring as well as age related concerns such as fine wrinkling.All the best, Dr Davin S. Lim & the team at Clinic Cutis. Brisbane. Australia.