High cholesterol can be significantly high and chronic in nature, or new and slightly in the abnormal range. Risks vary with each of these scenarios, bu to put things in perspective, smoking is a more immediate risk since circulation impairment from nicotine can cause dead skin and open wounds, so that would be considered a "higher" risk.If you are otherwise young, healthy, a non-smoker, and have a slightly elevated cholesterol, your risks are very low overall for any complication, including cardiovascular ones. But if you are older, overweight, and have a chronically high cholesterol, then your risks overall are still quite low, but indeed higher than the previous example.Since you need a pre-operative physical by your family physician, internist, or Gyn specialist before surgery, this will all be addressed before you proceed with breast reduction surgery. Follow your doctor's advice regarding your cholesterol and then follow your plastic surgeon's advice regarding breast reduction, but don't worry. This is an excellent operation with minimal blood loss and minimal "stress" to your system. Best wishes! Dr. Tholen