Thank you for your question. I understand you’d like to know which treatment is better for hair fall — PRP or mesotherapy.Just a bit about my background — I’m a Board-certified cosmetic surgeon and Fellowship-trained oculofacial plastic surgeon, practicing in Manhattan and Long Island for over 20 years, and performing hair transplants for that long as well. I’m the founder of TrichoStem™ Hair Regeneration centers, which offers a non-surgical hair loss treatment using a combination of platelet-rich plasma and extracellular matrix.To begin with, PRP, or platelet-rich plasma, is derived from your own blood, and is a concentration of healing and growth factors that will stimulate key elements in the skin when injected. It improves blood supply, fat cells, collagen, and stimulates short-term hair growth. The challenge with PRP injections, however, is that you will need frequently monthly injections as the effects cannot be sustained long-term.Mesotherapy, on the other hand, is comprised of various vitamin solutions and other things that are injected to areas of the scalp. I personally do not perform mesotherapy, but based on my own understanding of it, and with all due respect to those who practice it, I would not consider mesotherapy to be of any value for hair loss because hair loss is 90% due to genetics, and not because of a vitamin or nutritional deficiency.The usual ways of managing hair loss in the United States is by means of pharmaceuticals such as minoxidil and finasteride, or by means of hair restoration surgery like a hair transplant. However, because of a variety of reasons and limitations — for example, risks of sexual dysfunction in men who take finasteride, and limited effectiveness of hair transplants — people tend not to opt for these treatments.Which is why in our practice, we developed Hair Regeneration, which is a non-surgical hair loss treatment based on the wound healing technology of a material called extracellular matrix, combined with platelet-rich plasma. When using this combination, we discovered that we could stop hair progression, thicken existing thinning hairs, and in hair transplants improve donor area healing, and improve the survival rate of hair grafts. What is especially notable is that we are able to do a single injection treatment and see significant improvement over the course of a year to 18 months. In some advanced hair loss cases, we do a second injection at the 12th-18th month, in order to further build upon the first treatment.Backed up by 5 years worth of clinical data, we’ve been able to verify that Hair Regeneration is indeed sustainable without the need for frequent injections, and can stop the progression of hair loss, which I think is an important differentiator from both PRP and mesotherapy. I realize that your question is slightly different, but since you are looking into non-surgical alternatives, I thought it would be important for you to gain a bit more perspective on the matter and learn that there is another treatment you can look into, in addition to PRP and mesotherapy.I recommend that you try to learn more about this option, not to confuse you, but to ensure that you are educated about all the options there are out there. It would be good for you to learn and do more research so that you feel comfortable about your knowledge and the understanding of what the long-term plan is. Think in terms of years and decades and not just short-term solutions.I hope that was helpful and I wish you the best of luck!