Using isotretinoin but no improvement. Any suggestions?

Accutane is a go-to medication for patients with recalcitrant cystic acne. It can reduce pore size and also reduce sebum production in your skin, making it less oily; and in turn, dryer. Accutane can be used to control acne, but patients receiving the medication should be carefully monitored. In terms of skincare, always wear an appropriate sunscreen and reduce direct sun exposure. In my patients, I recommend a good ceramide moisturizer such as Elevase whenever they are on Accutane. This will keep the skin hydrated and reduce the oiliness of the skin that is associated with oil-based moisturizers.

Best,
Dr. Karamanoukian
Realself100 Surgeon

Thank you for your question. It is not uncommon to have acne breakouts while on Accutane therapy, especially within the first few weeks of treatment. Usually the flare-up lasts a couple of weeks, but in some individuals, the flare-up can be very severe and occur for several months. Please be patient with the treatment because acne tends to get worse before it gets better. The side effects you are experiencing are common, but the severity may be caused by the dose you are taking. I recommend you consult with your dermatologist regarding your concerns and to discuss any further questions you may have with therapy.Take care and good luck.