Is it possible to develop gynecomastia by using dutasteride applications?

Question

Is there by systemic absorption of dutasteride if it's given by injections other than orally? For to be able to develop gynecomastia? Or both methods can result in it? Thanks!

Ryan Goerig, MD, FAAD · Answer

Systemic absorption of topical dutasteride solution has not been validated and is unknown. That being said, there may be some that does in fact get in the bloodstream. That is why I would never recommend a pregnant or lactating person use dutasteride in any vehicle. Injectable dutasteride is a highly uncertain treatment for some types of hair loss, and is best not used at all. In conclusion, the likelihood of developing gynecomastia with topically applied or injected dutasteride is theoretically possible but highly unlikely.

Matt Tahsini, MD · Answer

Hello and thank you for your question. To my knowledge there have not been many studies on Gynecomastia and the use of Dutasteride. If you see this developing I suggest you discontinue using Dutasteride and contact your doctor. Best of luck to you.

Dr. T

Dr. T

Wipawan Vathananai, MD · Answer

Gynecomastia development after systemic dutasteride has been reported. However, there have not yet been reports of this side effect with intralesional dutasteride (or dutasteride mesotherapy) since the treatment is still relatively new. Gynecomastia is reversible with discontinuation of dutasteride.

Jeff Donovan, MD, PhD · Answer

Studies of dutasteride mesotherapy are way way too small to have any idea as to whether gynaecomastia is a risk or not. The risk of gynaecomastia is approximately one in 300 to 1 in 500 with typical males using oral dutasteride for androgenetic alopecia. That means in order to really understand this is side effect with meso a high number of patients will be needed. This has not been done. It’s almost certainly less of a risk but whether the risk is zero in completely unknown.

Is it possible to develop gynecomastia by using dutasteride applications?

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