Tri-Luma is typically recommended to be stored in the refrigerator to maintain its effectiveness, as it contains ingredients like hydroquinone, tretinoin, and fluocinolone acetonide, which can be sensitive to temperature changes. However, if it was left unrefrigerated for about 72 hours, it may still be effective, although there could be some minor reduction in potency. Here are a few suggestions: Check the Product: Before using it, examine the cream for any changes in color, consistency, or smell. If it appears altered, it might be best to replace it. Store Properly Moving Forward: Ensure that the cream is stored in the refrigerator from now on to preserve its effectiveness. Monitor Results: If you notice a decrease in effectiveness or any skin reaction, consult your dermatologist for advice. Consult a Professional: If you have concerns about its stability or effectiveness, consider reaching out to your pharmacist or dermatologist for further guidance. While short periods at room temperature might not significantly impact the effectiveness, it's always best to follow the storage instructions provided to ensure optimal results.