This is a good question but also a complex one which I can’t answer fully via this forum. Latisse contains bimatoprost as well as the preservative benzaalkonium chloride (BAC) at a concentration of 0.05 mg per mL. This preservative has been around since 1935. It is quite common in many products, especially those used around the eye. BAC is more likely to cause irritation than true allergy but certainly cases of allergic reactions can occur with BAC even serious ones. Studies at the Mayo clinic published in 2016 (see reference below) suggested that allergies to BAC might be increasing in the population. In fact, the allergen climbed up the list to now be one of their top 10 allergens they see in their clinic. It is far more likely that an allergy exists if the eyelids show some redness. But even without redness a systemic allergic response is still possible. With these sorts of situations, I like to know the whole story (and see the rashes if they are present). I like to know if the patient uses products containing BAC in the past and if so, what types of reactions they had. It’s a good idea to review the whole story with your physician. If it was only itching, one might (on the advice of the doctor) wait for the itching to go away completely and either try again or have a specialized physician test the product’s allergic potential on the skin as a prick or patch test. However, if there was any runny nose, cough, chest tightness, wheezing, shortness of breath, dizziness, throat tightness, swollen tongue or eyelid swelling...one should should seek the advice of an allergist physician. Wentworth A et al. Benzalkonium Chloride: A Known Irritant and Novel Allergen. Dermatitis 2016.