I have read that Vitamin E is beneficial while taking Claravis. Why?

Question

I am just starting my journey tomorrow. 30mg 1x per day to start / I weigh 115# / Female 48, non-child bearing I also read eating too much fish and dark greens is not good due to the Vitamin A it contains. I typically consume salmon and often another fish 1-3x per week and love my mixed green salads for lunch, along with kale ocassionally.

Daniel Navi, MD, FAAD · Answer

Whether or not Vitamin E can be beneficial while on isotretinoin is not yet fully clear based on available data. Previously it was felt that Vitamin E could reduce some of the side effects associated with isotretinoin including dry skin and chapped lips and thus some dermatologists recommended Vitamin E supplementation while on isotretinoin. However, more recent data suggests that Vitamin E supplementation may not improve side effects of isotretinoin and will not improve acne severity compared to those not taking Vitamin E supplements. 
With regards to diet while on isotretinoin it is advised to avoid any Vitamin A supplements or limit intake of foods that contain high levels of Vitamin A such as carrots, fish and dark green leafy vegetables. The reason for this is that these may make the side effects of isotretinoin more severe because isotretinoin is itself a Vitamin A derivative. Furthermore, a low fat diet is also recommended while on isotretinoin in order to reduce potential side effect of cholestrol and triglyceride elevation which is commonly seen during isotretinoin therapy.

I have read that Vitamin E is beneficial while taking Claravis. Why?

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