We combine Clear and Brilliant with PRP on the same day. However, you may wait 1 week to get it done. This is not an aggressive treatment its something people do every 2-4 weeks to keep their skin clear. We combine this with prp/microneedling, other lasers and peels at the same time. I suggest a combination approach of : For facial rejuvenation I would suggest a combination approach of : 1) skin care with products and PRP/microneedling 2) PDT light therapy few times a month with growth factors 3) laser treatments like clear and brilliant regularly and a few times a year Fraxel, Viva, Co2/Erbium 4) Sculptra injections a few times a year for collagen production with fillers like juvederm/restylane/belotero/radiesse/bellafill 5) thermage/ultherapy for yearly skin tightening with or without PDO or cone based instalift threads for lifting 6) botox every 2-3 months to stop movement lines and prevent lines at restSee the link provided that takes you to emeragecosmetics.com where we do free skincare consultations and offer medical grade products.Best, Dr. Emer.