Thank you for your question regarding the potential link between silicone injections and muscle atrophy in your legs. I understand your concerns related to the difficulties you are experiencing with walking and standing, along with the observed shrinking of your leg muscles. Injecting silicone into the body can potentially lead to muscle wasting or atrophy. This could occur due to the body's inflammatory response that gets triggered upon silicone injection. Your body naturally responds to the injected silicone by forming scar tissue. This scar tissue can surround and exert pressure on the nearby nerves. In cases where these nerves are chronically compressed, it can lead to muscle atrophy or shrinking. In your situation, it is crucial that you consult with both a neurologist and a plastic surgeon who specializes in silicone removal. They can collaborate to create a comprehensive diagnostic approach for your situation. The diagnostic plan should include imaging studies such as Magnetic Resonance Imaging (MRI) of both your buttock and thighs to assess the extent and location of the silicone. The MRI can provide detailed images of the soft tissues and detect any potential pressure on the nerves due to scar tissue formation. Additionally, an Electromyography (EMG) test should be included in your diagnostic plan. This test evaluates the health condition of muscles and the nerve cells that control them. It can provide useful information regarding any nerve or muscle damage caused by silicone injections. Bloodwork should also be carried out to rule out any other potential causes of your muscle wasting, ensuring a comprehensive approach to your medical concerns. In light of the problems you're facing, I strongly recommend considering silicone removal. This step could prevent the further progression of your symptoms and potential complications. Lastly, you might also be experiencing a group of symptoms known as Asia syndrome. This syndrome, also known as Autoimmune/Inflammatory Syndrome Induced by Adjuvants (ASIA), can be experienced by individuals who have had silicone injections. If this is the case, removing the silicone may also help alleviate these symptoms. Thank you for reaching out with your concerns about muscle wasting due to silicone injections. I hope this information is helpful and encourages you to seek prompt medical attention. Sincerely, Dr. Katzen