Is Sculptra safe for Hypermobile Ehlers Danlos Syndrome?

Question

I’m female, mid 40s, and have Hypermobile Ehlers Danlos syndrome. I also have marionette lines that I hate, and increasing nasiolabial folds and volume loss in my cheeks. Given all the areas of concern, and that filler lasts abt 3 months for me (I work out a lot), I was considering something like Sculptra. My skin is not overly stretchy or fragile, I have a lot of tattoos that healed fine. I’m terrified of granulomas. I’m not sure if Sculptra is something that will be ok for me with my condition

Anna Chacon, MD, FAAD · Answer

While Sculptra, a poly-L-lactic acid-based injectable, is generally considered safe for most individuals, there's limited specific research on its use in people with Hypermobile Ehlers-Danlos Syndrome (hEDS). 
hEDS is a connective tissue disorder that can affect skin's elasticity and healing. As Sculptra works by stimulating the body's collagen production, the altered collagen synthesis or regulation in hEDS might potentially influence the effectiveness or safety of Sculptra treatments. 
However, the decision to use Sculptra should be made on an individual basis, considering the patient's overall health, potential risks, and benefits. It's crucial to have a thorough conversation with a healthcare provider experienced in both hEDS and aesthetic medicine to make an informed decision.
Please note that this information should not replace professional medical advice. Always consult with a healthcare provider for personal medical advice.

Stephen Matta, DO · Answer

Sculptra is made of PLLA which is typically made from fermented plant starch such as from corn, cassava, sugarcane or sugar beet pulp. PLLA is also used to make sutures because of its ability to dissolve over time and stimulate healthy soft tissue regeneration, especially collagen. There are no studies on the safety or efficacy of Sculptra in Ehlers Danlos patients, but based on how Sculptra works and the weak collagen production known to occur in EDS, you may get a response ranging from not effective at all to fairly decent. Granulomas will likely only occur if not massaging the area often enough. Hope that helps!

Is Sculptra safe for Hypermobile Ehlers Danlos Syndrome?

Answers (2)

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