Is it safe for him to continue with wrestling during Accutane treatment?

Although safe to continue with contact sports while on Accutane, I always warn my patients that they may experience fatigue or joint and muscle aches while on Accutane, so they perform below their potential in competitive sports.

There is no reason your son should stop his wrestling if he is on an Accutane regimen. "This answer has been solicited without seeing this patient and
cannot be held as true medical advice, but only opinion. Seek in-person
treatment with a trained medical professional for appropriate care."