Areil, It is perfectly safe to get BOTOX while you are on Accutane except for one note of concern. Accutane is associated with a dry eye. If you are treated with BOTOX too aggressively, this can have an impact on the eyes ability to close appropriately. Under this circumstance, you might have a significantly increase in dry eye symptoms possibly requiring very active use of artificial tears and bedtime ointment. Make sure that the doctor doing your BOTOX is aware of the fact that you are on Accutane and is prepared to manage your dry eye symptoms if necessary. Avoid treatment to the lower eyelid. Your best bet is to find someone with a large experience treating with BOTOX. The Liquid facelift web site has a number of such individuals from a variety of specialties.