Hello, Microneedling is a safe treatment to combine with any filler including Botox. During the micro-needling procedure no pressure should be applied on the area being treated. The micro-needling pen is lightly placed on the skin moving in an upward and downward motion with no pressure applied, making it safe to use over any filler at any time. Some doctors may recommend you waiting a week or two between treatments depending on the your skin heals personally, everyone heals differently, some people have bruising and swelling with fillers that can take up to two weeks to heal, some people have swelling and redness with Microneedling for 5-7 days after. Everyone is different. Consult your Doctor for the best results according to your skin.