Consistent Botox injection into facial muscles can reduce the muscle mass by blocking the function of the muscles injected, causing the muscles to atrophy (or shrink) over time due to non-use. This effect of shrinking the muscles comes at the cost of muscle function. Botox is not intended to reshape the entire body. Not only would it take a huge amount of Botox to combat arm and leg muscles, but the function of your arm and leg muscles is not expendable. The best way to shrink these muscles is to not exercise them specifically. Also, is it really the muscle mass you are worried about, or overall volume? In most people excess arm or leg volume is fat, not muscle. If that is the case exercising and building those muscles will help burn the fat.