When considering the use of dermal fillers like Juvederm while undergoing immunotherapy with Avastin (bevacizumab), it is important to weigh potential interactions and risks. Key Considerations: Immunotherapy and Fillers: Avastin is an angiogenesis inhibitor that works by blocking the growth of new blood vessels to tumors. While it does not directly suppress the immune system, its effects on vascular health may theoretically influence healing and inflammation responses. Dermal fillers, including Juvederm, are generally considered safe for many patients, but they can cause localized inflammation, bruising, or swelling, which could be affected by concurrent treatments. Potential Risks: While there is no direct contraindication, the main concern is the body’s healing response. Avastin may affect wound healing, so any procedure that involves injections should be approached with caution. Discuss any history of side effects or complications with fillers, as the immune-modulating effects of your current treatment could potentially alter your reaction. Consultation with Healthcare Providers: It is crucial to consult with both your oncologist and a qualified dermatologist or cosmetic surgeon before proceeding with fillers. They can provide personalized advice based on your current treatment regimen and overall health. Ensure that any cosmetic procedures are performed by a professional who is aware of your medical history and current treatments. Timing and Monitoring: If approved by your healthcare team, consider timing the filler injections to avoid close proximity to your Avastin infusions, allowing your body time to recover and respond to each treatment separately. Monitor for any unusual reactions or side effects post-procedure and maintain open communication with your healthcare providers. Ultimately, while many patients do not experience issues with fillers during cancer treatments, individual circumstances vary. Personalized medical advice is essential to ensure safety and efficacy.