It is not clear to me from the question whether the term Botox was intended to cover all neuromodulators currently available (i.e. Dysport and Xeomin). In my nearly a quarter of a century using neuromodulators I have sometimes found that when one neuromodulator has not proven effective or sufficiently effective, substituting another, such as Xeomin, may prove to be.Moreover, occasionally the fault for lack of effect in treating platysmal banding may be the wrong technique or insufficient concentration or amounts of the neuromodulator injected. For best results I do not simply recommend the injection of the bands themselves, but a combination with a neuromodulator injection technique known as the "Nefertiti Lift," which, when performed properly, can result in additional, secondary upward pull on the neck. Finally, a technique known as The Nonsurgical 3D Vectoring Necklift, which uses volumizing fillers to provide "deep support volumetry" in order to achieve lifting and projection, in properly selected individuals, can yield quite gratifying results, especially when combined with neuromodulators. I have been routinely performing this technique for nearly a decade. The technique takes only about fifteen minutes to perform and the results are immediate and typically quite gratifying often engendering an immediate "Wow!" effect.I was one of the first to try threadlifting in the U.S. when it was introduced and approved in the early 2000s. I gave it up after only two years, since the procedure was expensive, minimally invasive, engendered down time, and mostly because the results did not last at best more than 8-12 months.I am not much of a fan of expensive treatments with fraxels, radiofrequency, and ultrasound devices, which often yield unimpressive, subtle and inconsistent results and are proving themselves to be far more device manufacturer supported marketing hype than hard science.For more information on the above techniques, check out the archives of RealSelf.com.Consultation with a board certifed aesthetician physician with experience and expertise in nonsurgical neck rejuvenation is a must. Insist upon seeing his/her before and after photos of nonsurgical neck rejuvenation in persons within your particular degree of banding and laxity.