Will Hylenex Dissolve Filler Encased in Biofilm?

Question

Will Hylenex dissolve filler encased in biofilm? After a half dozen shots, should Voluma biofilm reasonably have dissolved? Thanks.

Anna Chacon, MD, FAAD · Answer

Hylenex (hyaluronidase) is effective at dissolving hyaluronic acid-based fillers like Voluma, but when the filler is encased in a biofilm—a protective layer formed by bacteria—it can be more resistant to enzymatic breakdown. Biofilms can act as a physical barrier, making it harder for Hylenex to fully access and dissolve the filler.

In some cases, multiple sessions are needed, especially if the filler is deeply embedded or partially degraded. If you've already had about six rounds of Hylenex without significant improvement, it’s possible that a biofilm is impairing the response. In such scenarios, a combination approach using antibiotics to disrupt the biofilm, followed by additional Hylenex injections, may be more effective.

Persistent nodules or lack of resolution after multiple treatments warrant further evaluation, and in rare cases, surgical removal or biopsy may be considered.

Will Hylenex Dissolve Filler Encased in Biofilm?

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Will Hylenex Dissolve Filler Encased in Biofilm?

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Everything you need to know about Dermal Fillers

Our mission is to create a world where every investment in modern beauty is Worth It.